Genomic profiling of malignant phyllodes tumors reveals aberrations in FGFR1 and PI-3 kinase/RAS signaling pathways and provides insights into intratumoral heterogeneity.

doi:10.1038/modpathol.2016.97

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Article

Genomic profiling of malignant phyllodes tumors reveals aberrations in FGFR1 and PI-3 kinase/RAS signaling pathways and provides insights into intratumoral heterogeneity.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2016

Liu Su-Yang, Joseph Nancy M, Ravindranathan Ajay, Stohr Bradley A, Greenland Nancy Y, Vohra Poonam, Hosfield Elizabeth, Yeh Iwei, Talevich Eric, Onodera Courtney, Van Ziffle Jessica A, Grenert James P, Bastian Boris C, Chen Yunn-Yi, Krings Gregor

Abstract excerpt

Malignant phyllodes tumors of the breast are poorly understood rare neoplasms with potential for aggressive behavior. Few efficacious treatment options exist for progressed or metastatic disease. The molecular features of malignant phyllodes tumors are poorly defined, and a deeper understanding of the genetics of these tumors may shed light on pathogenesis and progression and potentially identify novel treatment...

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Identifiers

PMID: 27255162
DOI: 10.1038/modpathol.2016.97

Genes

EGFR
FGFR1
TERT
BRAF
CDK4
MDM2
MED12
PTEN
SETD2
TSC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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