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Article

A novel epigenetic AML1‐ETO/THAP10/miR‐383 mini‐circuitry contributes to t(8;21) leukaemogenesis

24 May 2017

Abstract excerpt

DNA methylation patterns are frequently deregulated in t(8;21) acute myeloid leukaemia (AML), but little is known of the mechanisms by which specific gene sets become aberrantly methylated. Here, we found that the promoter DNA methylation signature of t(8;21) + AML blasts differs from that of t(8;21) AMLs. This study demonstrated that a novel hypermethylated zinc finger-containing protein, THAP10, is a target...

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Share to Acute Myeloid Leukemia Research
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Identifiers

PMID: 28539478
DOI: 10.15252/emmm.201607180

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