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A Study of Hypermethylated Circulating Tumor DNA as a Universal Colorectal Cancer Biomarker

2 Jun 2016

Abstract excerpt

BACKGROUND: Circulating tumor DNA (ctDNA) has emerged as a good candidate for tracking tumor dynamics in different cancer types, potentially avoiding repeated tumor biopsies. Many different genes can be mutated within a tumor, complicating procedures for tumor monitoring, even with highly sensitive next-generation sequencing (NGS) strategies. Droplet-based digital PCR (dPCR) is a highly sensitive and quantitative...

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PMID: 27251038
DOI: 10.1373/clinchem.2015.253609

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