Article
Functional analysis of human cytomegalovirus UL/b' region using SCID-hu mouse model.
Journal of medical virology - 1 Aug 2016
Dulal Kalpana, Cheng Tong, Yang Lianwei, Wang Wei, Huang Ying, Silver Benjamin, Selariu Anca, Xie Cynthia, Wang Dai, Espeseth Amy, Lin Yanzhen, Wen Lanling, Xia Ningshao, Fu Tong-Ming, Zhu Hua
Abstract excerpt
Human cytomegalovirus (HCMV) attenuated strains, Towne, and AD169, differ from prototypic pathogenic strains, such as Toledo, in that they are missing a ∼15-kb segment in the UL/b' region. In contrast to the attenuated strains, Toledo can replicate in human tissue implants in SCID (SCID-hu) mice. Thus, this model provides a unique in vivo system to study the mechanism of viral pathogenesis. Twenty-two ORFs have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.