Article
Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype.
PloS one - 1 Jan 2016
Kim Yeon-Jung, Lee Heun-Sik, Kim Yun Kyoung, Park Suyeon, Kim Jeong-Min, Yun Jun Ho, Yu Ho-Yeong, Kim Bong-Jo
Abstract excerpt
The single nucleotide polymorphism rs9939609 of the gene FTO, which encodes fat mass and obesity-associated protein, is strongly associated with obesity and type 2 diabetes (T2D) in multiple populations; however, the underlying mechanism of this association is unclear. The present study aimed to investigate FTO genotype-dependent metabolic changes in obesity and T2D. To elucidate metabolic dysregulation...
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