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Herpesvirus telomeric repeats facilitate genomic integration into host telomeres and mobilization of viral DNA during reactivation.

The Journal of experimental medicine - 14 Mar 2011

Kaufer Benedikt B, Jarosinski Keith W, Osterrieder Nikolaus

Abstract excerpt

Some herpesviruses, particularly lymphotropic viruses such as Marek's disease virus (MDV) and human herpesvirus 6 (HHV-6), integrate their DNA into host chromosomes. MDV and HHV-6, among other herpesviruses, harbor telomeric repeats (TMRs) identical to host telomeres at either end of their linear genomes. Using MDV as a natural virus-host model, we show that herpesvirus TMRs facilitate viral genome integration...

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Chickens
DNA, Viral
Herpesviridae
Marek Disease
Repetitive Sequences, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Activation

Virus Integration

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PMID: 21383055
DOI: 10.1084/jem.20101402
PMCID: PMC3058580

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