Haplotypes of the MTHFR gene are associated with an increased risk of breast cancer in a Han Chinese population in Gansu province.

doi:10.1002/iub.1509

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Article

Haplotypes of the MTHFR gene are associated with an increased risk of breast cancer in a Han Chinese population in Gansu province.

IUBMB life - 1 Jul 2016

Song Ailing, Zhao Lei, Li Yumin, Wu Li, Li Yu, Liu Xiaokang, Lan Shen

Abstract excerpt

Elevated homocysteine levels are a risk factor for breast cancer, although the mechanism underlying this effect is unknown. Genome-wide association studies were used to systematically identify genetic variants which were significantly associated with the circulating homocysteine concentration. To examine the role of homocysteine-related variants in the occurrence of breast cancer, we investigated the association...

Topics

Adult
Asian People
Breast Neoplasms
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Haplotypes
Homocysteine
Humans
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Polymorphism, Single Nucleotide
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 27237471
DOI: 10.1002/iub.1509

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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