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Article

The Heterodimeric TWIST1-E12 Complex Drives the Oncogenic Potential of TWIST1 in Human Mammary Epithelial Cells.

Neoplasia (New York, N.Y.) - 1 May 2016

Jacqueroud Laurent, Bouard Charlotte, Richard Geoffrey, Payen Léa, Devouassoux-Shisheboran Mojgan, Spicer Douglas B, Caramel Julie, Collin Guillaume, Puisieux Alain, Tissier Agnès, Ansieau Stéphane

Abstract excerpt

The TWIST1 embryonic transcription factor displays biphasic functions during the course of carcinogenesis. It facilitates the escape of cells from oncogene-induced fail-safe programs (senescence, apoptosis) and their consequent neoplastic transformation. Additionally, it promotes the epithelial-to-mesenchymal transition and the initiation of the metastatic spread of cancer cells. Interestingly, cancer cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27237323
DOI: 10.1016/j.neo.2016.03.007
PMCID: PMC4887617

Genes

TWIST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The Heterodimeric TWIST1-E12 Complex Drives the Oncogenic Potential of TWIST1 in Human Mammary Epithelial Cells.PMID 27237323Read ↗

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