Article
Persistence of HCV in Acutely-Infected Patients Depletes C24-Ceramide and Upregulates Sphingosine and Sphinganine Serum Levels.
International journal of molecular sciences - 13 Jun 2016
Grammatikos Georgios, Dietz Julia, Ferreiros Nerea, Koch Alexander, Dultz Georg, Bon Dimitra, Karakasiliotis Ioannis, Lutz Thomas, Knecht Gaby, Gute Peter, Herrmann Eva, Zeuzem Stefan, Mavromara Penelope, Sarrazin Christoph, Pfeilschifter Josef
Abstract excerpt
Hepatitis C virus (HCV) substantially affects lipid metabolism, and remodeling of sphingolipids appears to be essential for HCV persistence in vitro. The aim of the current study is the evaluation of serum sphingolipid variations during acute HCV infection. We enrolled prospectively 60 consecutive patients with acute HCV infection, most of them already infected with human immunodeficiency virus (HIV), and serum...
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