Article
Osteopontin affects macrophage polarization promoting endocytic but not inflammatory properties.
Obesity (Silver Spring, Md.) - 1 Jul 2016
Schuch Karina, Wanko Bettina, Ambroz Katharina, Castelo-Rosa Alexandra, Moreno-Viedma Verónica, Grün Nicole G, Leitner Lukas, Staffler Günther, Zeyda Maximilian, Stulnig Thomas M
Abstract excerpt
OBJECTIVE: Macrophages are the main drivers of obesity-induced adipose tissue (AT) inflammation that causes insulin resistance. Macrophages polarize toward different inflammatory (M1) or protective (M2) phenotypes. Osteopontin (OPN) is an inflammatory cytokine highly expressed in AT in obesity and known to be involved in chronic inflammatory processes. It was hypothesized that OPN polarizes macrophages into a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.