Article
From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Aug 2016
Luz Anthony L, Godebo Tewodros R, Bhatt Dhaval P, Ilkayeva Olga R, Maurer Laura L, Hirschey Matthew D, Meyer Joel N
Abstract excerpt
Millions of people worldwide are chronically exposed to arsenic through contaminated drinking water. Despite decades of research studying the carcinogenic potential of arsenic, the mechanisms by which arsenic causes cancer and other diseases remain poorly understood. Mitochondria appear to be an important target of arsenic toxicity. The trivalent arsenical, arsenite, can induce mitochondrial reactive oxygen...
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