Article
Coregulation of tandem duplicate genes slows evolution of subfunctionalization in mammals.
Science (New York, N.Y.) - 20 May 2016
Lan Xun, Pritchard Jonathan K
Abstract excerpt
Gene duplication is a fundamental process in genome evolution. However, most young duplicates are degraded by loss-of-function mutations, and the factors that allow some duplicate pairs to survive long-term remain controversial. One class of models to explain duplicate retention invokes sub- or neofunctionalization, whereas others focus on sharing of gene dosage. RNA-sequencing data from 46 human and 26 mouse...
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