Article
Patient-tailored analysis of minimal residual disease in acute myeloid leukemia using next-generation sequencing.
European journal of haematology - 1 Jan 2017
Malmberg Erik B R, Ståhlman Sara, Rehammar Anna, Samuelsson Tore, Alm Sofie J, Kristiansson Erik, Abrahamsson Jonas, Garelius Hege, Pettersson Louise, Ehinger Mats, Palmqvist Lars, Fogelstrand Linda
Abstract excerpt
Next-generation sequencing techniques have revealed that leukemic cells in acute myeloid leukemia often are characterized by a limited number of somatic mutations. These mutations can be the basis for the detection of leukemic cells in follow-up samples. The aim of this study was to identify leukemia-specific mutations in cells from patients with acute myeloid leukemia and to use these mutations as markers for...
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