Selenium and Vitamin E: Cell Type– and Intervention-Specific Tissue Effects in Prostate Cancer

Abstract excerpt

BACKGROUND: Secondary analyses of two randomized, controlled phase III trials demonstrated that selenium and vitamin E could reduce prostate cancer incidence. To characterize pharmacodynamic and gene expression effects associated with use of selenium and vitamin E, we undertook a randomized, placebo-controlled phase IIA study of prostate cancer patients before prostatectomy and created a preoperative model for...

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