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Article

p27 Is a Candidate Prognostic Biomarker and Metastatic Promoter in Osteosarcoma

20 Apr 2016

Abstract excerpt

Metastatic progression is the major cause of death in osteosarcoma, the most common bone malignancy in children and young adults. However, prognostic biomarkers and efficacious targeted treatments for metastatic disease remain lacking. Using an immunoproteomic approach, we discovered that autoantibodies against the cell-cycle kinase inhibitor p27 (KIP1, CDKN1B) were elevated in plasma of high-risk osteosarcoma...

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PMID: 27197201
DOI: 10.1158/0008-5472.can-15-3189

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