Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA-27a Promotes Proliferation, Migration and Invasion by Targeting<b><i>MAP2K4</i></b>in Human Osteosarcoma Cells

1 Jan 2014

Abstract excerpt

BACKGROUND: Osteosarcoma is a high-grade malignant bone neoplasm. Although the introduction of chemotherapy has reduced its mortality, more than 50% of patients develop chemoresistance and have an extremely poor prognosis due to pulmonary metastasis. Several molecular pathways contributing to osteosarcoma development and progression have recently been discovered. Various studies have addressed the genes involved...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Melanoma and MAPK Pathways
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24556602
DOI: 10.1159/000356679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-27a Promotes Proliferation, Migration and Invasion by Targeting<b><i>MAP2K4</i></b>in Human Osteosarcoma CellsPMID 24556602Read ↗

MicroRNA-342-3p Inhibits the Proliferation, Migration, and Invasion of Osteosarcoma Cells by Targeting Astrocyte-Elevated Gene-1 (AEG-1)Semantic proximity Read ↗

MicroRNA-744-5p Suppresses Tumorigenesis and Metastasis of Osteosarcoma Through the MAPK/ERK Signaling Pathway by Targeting TGFB1Semantic proximity Read ↗

<i>miRNA-34c</i> suppresses osteosarcoma progression <i>in vivo</i> by targeting Notch and E2FSemantic proximity Read ↗

Tumor-suppressor miRNA-27b-5p regulates the growth and metastatic behaviors of ovarian carcinoma cells by targeting CXCL1Semantic proximity Read ↗

Up-regulated MiR-27-3p promotes the G1-S phase transition by targeting inhibitor of growth family member 5 in osteosarcomaSemantic proximity Read ↗

Lentiviral expression of anti-microRNAs targeting miR-27a inhibits proliferation and invasiveness of U87 glioma cells.Semantic proximity Read ↗

miR-766-3p suppressed tumorigenesis, epithelial-mesenchymal transition, and metastasis by targeting BCL9L via β -catenin signaling pathway in osteosarcoma cellsSemantic proximity Read ↗

p27 Is a Candidate Prognostic Biomarker and Metastatic Promoter in OsteosarcomaSemantic proximity Read ↗

LncRNA GAS5 suppresses the proliferation and invasion of osteosarcoma cells via the miR-23a-3p/PTEN/PI3K/AKT pathwaySemantic proximity Read ↗

Exosomal miR-199a-5p Inhibits Tumorigenesis and Angiogenesis by Targeting VEGFA in OsteosarcomaSemantic proximity Read ↗

MiR-23a Functions as a Tumor Suppressor in OsteosarcomaSemantic proximity Read ↗

MicroRNA-494 inhibits cell proliferation and invasion of chondrosarcoma cells<i>in vivo</i>and<i>in vitro</i>by directly targeting SOX9Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.