Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts

14 Aug 2019

Abstract excerpt

Telomerase is a ribonucleoprotein complex that maintains the length and integrity of telomeres, and thereby enables cellular proliferation. Understanding the regulation of telomerase in hematopoietic cells is relevant to the pathogenesis of leukemia, in which telomerase is constitutively activated, as well as bone marrow failure syndromes that feature telomerase insufficiency. Past studies showing high levels of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Share to Nuclear Structure and Function
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31413099
DOI: 10.3324/haematol.2018.215699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblastsPMID 31413099Read ↗

Mutations of telomerase complex genes linked to bone marrow failures.Semantic proximity Read ↗

Dyskeratosis congenita: molecular insights into telomerase function, ageing and cancer.Semantic proximity Read ↗

Regulation of human telomerase in homeostasis and disease.Semantic proximity Read ↗

RIOK2 transcriptionally regulates TRiC and dyskerin complexes to prevent telomere shorteningSemantic proximity Read ↗

A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere SynthesisSemantic proximity Read ↗

Dyskeratosis CongenitaSemantic proximity Read ↗

Dyskeratosis congenita -- a disease of dysfunctional telomere maintenance.Semantic proximity Read ↗

Dyskeratosis congenita.Semantic proximity Read ↗

<i>MYC</i> -Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of DyskerinSemantic proximity Read ↗

Dyskeratosis congenita: telomerase, telomeres and anticipation.Semantic proximity Read ↗

The C-terminal extension of dyskerin is a dyskeratosis congenita mutational hotspot that modulates interaction with telomerase RNA and subcellular localization.Semantic proximity Read ↗

Dyskeratosis congenita mutations in dyskerin SUMOylation consensus sites lead to impaired telomerase RNA accumulation and telomere defects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.