Clinical Significance of TLR1 I602S Polymorphism for Patients with Metastatic Colorectal Cancer Treated with FOLFIRI plus Bevacizumab.

doi:10.1158/1535-7163.MCT-15-0931

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Article

Clinical Significance of TLR1 I602S Polymorphism for Patients with Metastatic Colorectal Cancer Treated with FOLFIRI plus Bevacizumab.

Molecular cancer therapeutics - 1 Jul 2016

Okazaki Satoshi, Loupakis Fotios, Stintzing Sebastian, Cao Shu, Zhang Wu, Yang Dongyun, Ning Yan, Sunakawa Yu, Stremitzer Stefan, Matsusaka Satoshi, Berger Martin D, Parekh Anish, West Jordan D, Miyamoto Yuji, Suenaga Mitsukuni, Schirripa Marta, Cremolini Chiara, Falcone Alfredo, Heinemann Volker, DePaolo R William, Lenz Heinz-Josef

Abstract excerpt

The purpose of this study was to evaluate the clinical significance of single-nucleotide polymorphisms in TLR1, TLR2, TLR6, and TAK1 in patients with metastatic colorectal cancer (mCRC). We genotyped 9 SNPs of TLR1, TLR2, TLR6, and TAK1 in mCRC patients treated with first-line FOLFIRI (combination therapy of irinotecan, 5-fluorouracil, and folinic acid) plus bevacizumab, using a discovery cohort (TRIBE trial, n =...

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Identifiers

PMID: 27196764
DOI: 10.1158/1535-7163.MCT-15-0931
PMCID: PMC4936942

Genes

TLR1
TLR2
TLR6

Variants

rs5743618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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