A Polymorphism within the Vitamin D Transporter Gene Predicts Outcome in Metastatic Colorectal Cancer Patients Treated with FOLFIRI/Bevacizumab or FOLFIRI/Cetuximab.

doi:10.1158/1078-0432.CCR-17-1663

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Article

A Polymorphism within the Vitamin D Transporter Gene Predicts Outcome in Metastatic Colorectal Cancer Patients Treated with FOLFIRI/Bevacizumab or FOLFIRI/Cetuximab.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2018

Berger Martin D, Stintzing Sebastian, Heinemann Volker, Cao Shu, Yang Dongyun, Sunakawa Yu, Matsusaka Satoshi, Ning Yan, Okazaki Satoshi, Miyamoto Yuji, Suenaga Mitsukuni, Schirripa Marta, Hanna Diana L, Soni Shivani, Puccini Alberto, Zhang Wu, Cremolini Chiara, Falcone Alfredo, Loupakis Fotios, Lenz Heinz-Josef

Abstract excerpt

Purpose: Vitamin D exerts its inhibitory influence on colon cancer growth by inhibiting Wnt signaling and angiogenesis. We hypothesized that SNPs in genes involved in vitamin D transport, metabolism, and signaling are associated with outcome in metastatic colorectal cancer (mCRC) patients treated with first-line FOLFIRI and bevacizumab.Experimental Design: 522 mCRC patients enrolled in the FIRE-3 (discovery...

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Identifiers

PMID: 29208668
DOI: 10.1158/1078-0432.CCR-17-1663
PMCID: PMC7505162

Genes

CST5
DKK1
VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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