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Article

Evolution of CCL11: genetic characterization in lagomorphs and evidence of positive and purifying selection in mammals.

Innate immunity - 1 Jul 2016

Neves Fabiana, Abrantes Joana, Esteves Pedro J

Abstract excerpt

The interactions between chemokines and their receptors are crucial for differentiation and activation of inflammatory cells. CC chemokine ligand 11 (CCL11) binds to CCR3 and to CCR5 that in leporids underwent gene conversion with CCR2. Here, we genetically characterized CCL11 in lagomorphs (leporids and pikas). All lagomorphs have a potentially functional CCL11, and the Pygmy rabbit has a mutation in the stop...

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Share to Biological Evolution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, CCR2

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Source

Identifiers

PMID: 27189425
DOI: 10.1177/1753425916647471

Genes

CCL11
CCR2
CCR3
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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