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RNA-Seq following PCR-based sorting reveals rare cell transcriptional signatures

17 May 2016

Abstract excerpt

BACKGROUND: Rare cell subtypes can profoundly impact the course of human health and disease, yet their presence within a sample is often missed with bulk molecular analysis. Single-cell analysis tools such as FACS, FISH-FC and single-cell barcode-based sequencing can investigate cellular heterogeneity; however, they have significant limitations that impede their ability to identify and transcriptionally...

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PMID: 27189161
DOI: 10.1186/s12864-016-2694-2

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