Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence

Abstract excerpt

Staphylococcus aureus is a significant cause of human infection. Here, we demonstrate that mutations in the transcriptional repressor of purine biosynthesis, purR, enhance the pathogenic potential of S. aureus. Indeed, systemic infection with purR mutants causes accelerated mortality in mice, which is due to aberrant up-regulation of fibronectin binding proteins (FnBPs). Remarkably, purR mutations can arise upon...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antimicrobial Resistance in Staphylococcus
• Share to Bacillus and Francisella bacterial research
• Share to Bacterial biofilms and quorum sensing