Article
Two MER2-negative individuals with the same novel CD151 mutation and evidence for clinical significance of anti-MER2.
Transfusion - 1 Sept 2008
Karamatic Crew Vanja, Poole Joyce, Long Shannon, Warke Nicole, Colavecchia Connie, Burton Nicholas, Moulds Marilyn, Schlanser Gloria, Wilson Laura, Noumsi Ghislain, Moulds Joann M, Moulds John J, Daniels Geoff
Abstract excerpt
BACKGROUND: MER2 (RAPH1), the only antigen of the RAPH blood group system, is located on the tetraspanin CD151. Only four examples of alloanti-MER2 are known. We report here two new examples of alloanti-MER2, in women of Pakistani and Turkish origin, one of whom showed signs of a hemolytic transfusion reaction (HTR) after transfusion of 3 units of red cells (RBCs). STUDY DESIGN AND METHODS: Standard serologic...
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