Article
The correlation of sodium iodide symporter and BRAF(V600E) mutation in classical variant papillary thyroid carcinoma.
Annals of diagnostic pathology - 1 Jun 2016
Yazgan Aylin, Yıldırım Nilüfer, Gözalan Ayşegül, Gümüştaş Sinem, Kılıçarslan Aydan, Balci Serdar, Aydın Cevdet, Ersoy Reyhan, Cakir Bekir, Güler Gülnur
Abstract excerpt
BRAF(V600E) mutation was analyzed by real-time polymerase chain reaction in 96 consecutive cases with classical variant papillary thyroid cancer, and immunohistochemical staining of Na+/I- symporter (NIS) protein was evaluated. Localization (intracellular or membranous), density, and the intensity of cytoplasmic staining were characterized semiquantitatively. Extrathyroidal invasion, surgical margin positivity,...
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