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Article

Patient-specific factors influence somatic variation patterns in von Hippel-Lindau disease renal tumours.

Nature communications - 13 May 2016

Fei Suzanne S, Mitchell Asia D, Heskett Michael B, Vocke Cathy D, Ricketts Christopher J, Peto Myron, Wang Nicholas J, Sönmez Kemal, Linehan W Marston, Spellman Paul T

Abstract excerpt

Cancer development is presumed to be an evolutionary process that is influenced by genetic background and environment. In laboratory animals, genetics and environment are variables that can largely be held constant. In humans, it is possible to compare independent tumours that have developed in the same patient, effectively constraining genetic and environmental variation and leaving only stochastic processes....

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Identifiers

PMID: 27174753
DOI: 10.1038/ncomms11588
PMCID: PMC4869254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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