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Article

VAV3 Gene Polymorphism Is Associated with Paget's Disease of Bone.

Genetic testing and molecular biomarkers - 1 Jun 2016

Usategui-Martín Ricardo, Calero-Paniagua Ismael, García-Aparicio Judith, Corral-Gudino Luis, Del Pino Montes Javier, González Sarmiento Rogelio

Abstract excerpt

BACKGROUND AND AIMS: Paget's disease of bone (PDB) is a focal bone disorder affecting the skeleton segmentally. The disease affects osteoclasts which increase in size, number, and activity. One of the etiopathogenic hypotheses is that the disease is genetic. It has been reported that Rho GEF Vav3 is an essential factor in the regulation of osteoclast function, and alteration of the VAV3 gene could influence the...

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Source

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Identifiers

PMID: 27172236
DOI: 10.1089/gtmb.2015.0292
PMCID: PMC4892207

Genes

VAV3

Variants

rs7528153

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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