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Article

Evaluation of IRX Genes and Conserved Noncoding Elements in a Region on 5p13.3 Linked to Families with Familial Idiopathic Scoliosis and Kyphosis.

G3 (Bethesda, Md.) - 1 Jun 2016

Justice Cristina M, Bishop Kevin, Carrington Blake, Mullikin Jim C, Swindle Kandice, Marosy Beth, Sood Raman, Miller Nancy H, Wilson Alexander F

Abstract excerpt

Because of genetic heterogeneity present in idiopathic scoliosis, we previously defined clinical subsets (a priori) from a sample of families with idiopathic scoliosis to find genes involved with spinal curvature. Previous genome-wide linkage analysis of seven families with at least two individuals with kyphoscoliosis found linkage (P-value = 0.002) in a 3.5-Mb region on 5p13.3 containing only three known genes,...

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Share to Animals, Genetically Modified
Share to Chromosomes, Human, Pair 5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27172222
DOI: 10.1534/g3.116.029975
PMCID: PMC4889666

Genes

IRX1
IRX2
IRX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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