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Article

Essential control of mitochondrial morphology and function by chaperone-mediated autophagy through degradation of PARK7

12 May 2016

Abstract excerpt

As a selective degradation system, chaperone-mediated autophagy (CMA) is essential for maintaining cellular homeostasis and survival under stress conditions. Increasing evidence points to an important role for the dysfunction of CMA in the pathogenesis of Parkinson disease (PD). However, the mechanisms by which CMA regulates neuronal survival under stress and its role in neurodegenerative diseases are not fully...

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Identifiers

PMID: 27171370
DOI: 10.1080/15548627.2016.1179401

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