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Article

Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current.

Heart rhythm - 1 Aug 2016

Yu Chih-Chieh, Ko Jum-Suk, Ai Tomohiko, Tsai Wen-Chin, Chen Zhenhui, Rubart Michael, Vatta Matteo, Everett Thomas H, George Alfred L, Chen Peng-Sheng

Abstract excerpt

BACKGROUND: Apamin-sensitive small-conductance calcium-activated potassium (SK) channels are gated by intracellular Ca(2+) through a constitutive interaction with calmodulin. OBJECTIVE: We hypothesize that arrhythmogenic human calmodulin mutations impede activation of SK channels. METHODS: We studied 5 previously published calmodulin mutations (N54I, N98S, D96V, D130G, and F90L). Plasmids encoding either...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27165696
DOI: 10.1016/j.hrthm.2016.05.009
PMCID: PMC4958519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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