Article
Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death.
American journal of human genetics - 5 Oct 2012
Nyegaard Mette, Overgaard Michael T, Søndergaard Mads T, Vranas Marta, Behr Elijah R, Hildebrandt Lasse L, Lund Jacob, Hedley Paula L, Camm A John, Wettrell Göran, Fosdal Inger, Christiansen Michael, Børglum Anders D
Abstract excerpt
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a devastating inherited disorder characterized by episodic syncope and/or sudden cardiac arrest during exercise or acute emotion in individuals without structural cardiac abnormalities. Although rare, CPVT is suspected to cause a substantial part of sudden cardiac deaths in young individuals. Mutations in RYR2, encoding the cardiac sarcoplasmic...
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