Article
ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice.
Proceedings of the National Academy of Sciences of the United States of America - 24 May 2016
Diaz-Horta Oscar, Abad Clemer, Sennaroglu Levent, Foster Joseph, DeSmidt Alexandra, Bademci Guney, Tokgoz-Yilmaz Suna, Duman Duygu, Cengiz F Basak, Grati M'hamed, Fitoz Suat, Liu Xue Z, Farooq Amjad, Imtiaz Faiqa, Currall Benjamin B, Morton Cynthia Casson, Nishita Michiru, Minami Yasuhiro, Lu Zhongmin, Walz Katherina, Tekin Mustafa
Abstract excerpt
Hair cells of the inner ear, the mechanosensory receptors, convert sound waves into neural signals that are passed to the brain via the auditory nerve. Little is known about the molecular mechanisms that govern the development of hair cell-neuronal connections. We ascertained a family with autosomal recessive deafness associated with a common cavity inner ear malformation and auditory neuropathy. Via whole-exome...
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