Article
Chronic stress does not further exacerbate the abnormal psychoneuroendocrine phenotype of Cbg-deficient male mice.
Psychoneuroendocrinology - 1 Aug 2016
de Medeiros Gabriela F, Minni Amandine M, Helbling Jean-Christophe, Moisan Marie-Pierre
Abstract excerpt
Chronic stress leads to a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis which can constitute a base for pathophysiological consequences. Using mice totally deficient in Corticosteroid binding globulin (CBG), we have previously demonstrated the important role of CBG in eliciting an adequate response to an acute stressor. Here, we have studied its role in chronic stress situations. We have...
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