Cholesterol feeding accentuates the cyclosporine-induced elevation of renal plasminogen activator inhibitor type 1.

doi:10.1038/ki.1997.249

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Article

Cholesterol feeding accentuates the cyclosporine-induced elevation of renal plasminogen activator inhibitor type 1.

Kidney international - 1 Jun 1997

Duymelinck C, Dauwe S E, Nouwen E J, De Broe M E, Verpooten G A

Abstract excerpt

Long-term cyclosporine (CsA) therapy is accompanied by the occurrence of hypercholesterolemia and renal interstitial fibrosis. The present study investigates the effect of dietary cholesterol on CsA-induced lipid disturbances in the rat and on CsA nephrotoxicity. Since plasminogen activator inhib...

Topics

Animals
Body Weight
Cell Division
Cholesterol, Dietary
Cyclosporine
Immunohistochemistry
Immunosuppressive Agents
Kidney
Lipids
Male
Phenotype
Plasminogen Activator Inhibitor 1
Rats
Rats, Wistar
Staining and Labeling

Source

Open in PubMed

Identifiers

PMID: 9186871
DOI: 10.1038/ki.1997.249

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9186871-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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