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Article

Distinct Genetic Risk Profile of the Rapidly Progressing Diffuse-Trickling Subtype of Geographic Atrophy in Age-Related Macular Degeneration (AMD).

Investigative ophthalmology & visual science - 1 May 2016

Fleckenstein Monika, Grassmann Felix, Lindner Moritz, Pfau Maximilian, Czauderna Joanna, Strunz Tobias, von Strachwitz Claudia, Schmitz-Valckenberg Steffen, Holz Frank G, Weber Bernhard H F

Abstract excerpt

PURPOSE: To genetically characterize a subphenotype of geographic atrophy (GA) in AMD associated with rapid progression and a diffuse-trickling appearance on fundus autofluorescence imaging. METHODS: Patients from the Fundus Autofluorescence in Age-Related Macular Degeneration Study were phenotyped for diffuse-trickling GA (dt-GA; n = 44). DNA was analyzed for 10 known AMD-associated genetic variants. A genetic...

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Source

Identifiers

PMID: 27149696
DOI: 10.1167/iovs.15-18593

Genes

CFH
ARMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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