RADseq underestimates diversity and introduces genealogical biases due to nonrandom haplotype sampling.

doi:10.1111/mec.12276

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Article

RADseq underestimates diversity and introduces genealogical biases due to nonrandom haplotype sampling.

Molecular ecology - 1 Jun 2013

Arnold B, Corbett-Detig R B, Hartl D, Bomblies K

Abstract excerpt

Reduced representation genome-sequencing approaches based on restriction digestion are enabling large-scale marker generation and facilitating genomic studies in a wide range of model and nonmodel systems. However, sampling chromosomes based on restriction digestion may introduce a bias in allele frequency estimation due to polymorphisms in restriction sites. To explore the effects of this nonrandom sampling and...

Topics

Animals
Biodiversity
Chromosome Mapping
Drosophila melanogaster
Genetic Variation
Haplotypes
High-Throughput Nucleotide Sequencing
Metagenome
Metagenomics
Polymorphism, Single Nucleotide
Sequence Analysis, DNA

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Open in PubMed

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PMID: 23551379
DOI: 10.1111/mec.12276

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