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Article

RADseq underestimates diversity and introduces genealogical biases due to nonrandom haplotype sampling.

Molecular ecology - 1 Jun 2013

Arnold B, Corbett-Detig R B, Hartl D, Bomblies K

Abstract excerpt

Reduced representation genome-sequencing approaches based on restriction digestion are enabling large-scale marker generation and facilitating genomic studies in a wide range of model and nonmodel systems. However, sampling chromosomes based on restriction digestion may introduce a bias in allele frequency estimation due to polymorphisms in restriction sites. To explore the effects of this nonrandom sampling and...

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Identifiers

PMID: 23551379
DOI: 10.1111/mec.12276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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