Polymorphisms in CYP19A1 and NFKB1 genes are associated with cutaneous melanoma risk in southern Brazilian patients.

doi:10.1097/CMR.0000000000000267

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Article

Polymorphisms in CYP19A1 and NFKB1 genes are associated with cutaneous melanoma risk in southern Brazilian patients.

Melanoma research - 1 Aug 2016

Escobar Gabriela F, Arraes Jose Aroldo A, Bakos Lucio, Ashton-Prolla Patricia, Giugliani Roberto, Callegari-Jacques Sidia Maria, Santos Sidney, Bakos Renato M

Abstract excerpt

BACKGROUND: Melanoma is the leading cause of death from skin cancers and its etiology is complex. Recent discoveries related to genetic risk factors are helping us to understand melanoma pathogenesis better. Nuclear factor-κB (NF-κB) has a critical role in immunity, inflammation, and tumor growth. The 94ins/del ATTG (rs28362491) polymorphism located in the NFKB1 gene has been associated to various cancers and the...

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PMID: 27145040
DOI: 10.1097/CMR.0000000000000267

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NFKB1

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