Deregulation in STAT signaling is important for cutaneous T-cell lymphoma (CTCL) pathogenesis and cancer progression

Abstract excerpt

Deregulation of STAT signaling has been implicated in the pathogenesis for a variety of cancers, including CTCL. Constitutive activation of STAT5 and STAT3 was observed in early and late stages of CTCL, respectively. In early stages, IL-2, IL-7 and IL-15 signaling via JAK1 and JAK3 kinases is believed to be responsible for activating STAT5, while in advanced stages development of IL-21 autocrine signaling is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cutaneous lymphoproliferative disorders research
• Share to Lymphoma Diagnosis and Treatment
• Share to T-cell and Retrovirus Studies