Article
Crystallographic snapshots of oxalyl-CoA decarboxylase give insights into catalysis by nonoxidative ThDP-dependent decarboxylases.
Structure (London, England : 1993) - 1 Jul 2007
Berthold Catrine L, Toyota Cory G, Moussatche Patricia, Wood Martin D, Leeper Finian, Richards Nigel G J, Lindqvist Ylva
Abstract excerpt
Despite more than five decades of extensive studies of thiamin diphosphate (ThDP) enzymes, there remain many uncertainties as to how these enzymes achieve their rate enhancements. Here, we present a clear picture of catalysis for the simple nonoxidative decarboxylase, oxalyl-coenzyme A (CoA) decarboxylase, based on crystallographic snapshots along the catalytic cycle and kinetic data on active site mutants....
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