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Article

The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound.

Biochemistry - 28 Jun 2005

Lobley Carina M C, Ciulli Alessio, Whitney Heather M, Williams Glyn, Smith Alison G, Abell Chris, Blundell Tom L

Abstract excerpt

The NADPH-dependent reduction of ketopantoate to pantoate, catalyzed by ketopantoate reductase (KPR; EC 1.1.1.169), is essential for the biosynthesis of pantothenate (vitamin B(5)). Here we present the crystal structure of Escherichia coli KPR with NADP(+) bound, solved to 2.1 A resolution. The cofactor is bound in the active site cleft between the N-terminal Rossmann-fold domain and the C-terminal alpha-helical...

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Identifiers

PMID: 15966718
DOI: 10.1021/bi0502036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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