Article
Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.
Molecular neurodegeneration - 30 Apr 2016
Alquezar Carolina, Salado Irene G, de la Encarnación Ana, Pérez Daniel I, Moreno Fermín, Gil Carmen, de Munain Adolfo López, Martínez Ana, Martín-Requero Ángeles
Abstract excerpt
BACKGROUND: Mutations in the progranulin gene (GRN) are the most common cause of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). TDP-43 pathology is characterized by the hyperphosphorylation of the protein at Serine 409/410 residues. Casein kinase-1δ (CK-1δ) was reported to phosphorylate TDP-43 directly. Previous works from our laboratory described the presence of CDK6/pRb-dependent cell...
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