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Article

Increasing progranulin levels and blockade of the ERK1/2 pathway: upstream and downstream strategies for the treatment of progranulin deficient frontotemporal dementia.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Mar 2015

Alquezar Carolina, Esteras Noemí, de la Encarnación Ana, Moreno Fermín, López de Munain Adolfo, Martín-Requero Ángeles

Abstract excerpt

Frontotemporal lobar degeneration (FTLD) is a neurodegenerative disorder marked by mild-life onset and progressive changes in behavior, social cognition, and language. Loss-of-function progranulin gene (GRN) mutations are the major cause of FTLD with TDP-43 protein inclusions (FTLD-TDP). Disease-...

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Source

Identifiers

PMID: 25624003
DOI: 10.1016/j.euroneuro.2014.12.007

Genes

GRN
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25624003-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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