BRAF(V600E) Mutation is Associated with Decreased Disease-Free Survival in Papillary Thyroid Cancer.

doi:10.1007/s00268-016-3534-x

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Article

BRAF(V600E) Mutation is Associated with Decreased Disease-Free Survival in Papillary Thyroid Cancer.

World journal of surgery - 1 Jul 2016

Fraser S, Go C, Aniss A, Sidhu S, Delbridge L, Learoyd D, Clifton-Bligh R, Tacon L, Tsang V, Robinson B, Gill A J, Sywak M

Abstract excerpt

BACKGROUND: The BRAF (V600E) mutation is a recognised molecular marker in papillary thyroid cancer (PTC), reported incidence from 30 to 80 %. BRAF(V600E) aberrantly activates the MAPK pathway, a central regulator of cell growth and proliferation. Previous studies have reported conflicting data regarding the impact of BRAF(V600E) on clinicopathological features of PTC. The study aims to determine whether...

Topics

Ablation Techniques
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Carcinoma
Carcinoma, Papillary
Child
Cohort Studies
Disease-Free Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Humans

Iodine Radioisotopes

Lymphatic Metastasis

Male

Middle Aged

Mutation

Source

Open in PubMed

Identifiers

PMID: 27138882
DOI: 10.1007/s00268-016-3534-x

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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