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Article

BRAF(V600E) mutation is associated with an increased risk of nodal recurrence requiring reoperative surgery in patients with papillary thyroid cancer.

Surgery - 1 Dec 2010

O'Neill Christine J, Bullock Martyn, Chou Angela, Sidhu Stan B, Delbridge Leigh W, Robinson Bruce G, Gill Anthony J, Learoyd Diana L, Clifton-Bligh Roderick, Sywak Mark S

Abstract excerpt

BACKGROUND: The role of the B-isoform of the Raf kinase (BRAF) mutation BRAF(V600E) as an independent prognostic factor in papillary thyroid cancer (PTC) remains controversial. Some studies suggest that tumors containing BRAF(V600E) have decreased radioiodine avidity and present a greater risk of nodal recurrence and distant metastases. METHODS: Paraffin-embedded specimens from consecutive patients who underwent...

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Source

Identifiers

PMID: 21134544
DOI: 10.1016/j.surg.2010.09.005

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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BRAF(V600E) mutation is associated with an increased risk of nodal recurrence requiring reoperative surgery in patients with papillary thyroid cancer.PMID 21134544Read ↗

The <i>BRAF</i> mutation is useful for prediction of clinical recurrence in low‐risk patients with conventional papillary thyroid carcinomaSemantic proximity Read ↗

BRAF(V600E) Mutation is Associated with Decreased Disease-Free Survival in Papillary Thyroid Cancer.Semantic proximity Read ↗

BRAFV600E Mutation is Associated with an Increased Risk of Papillary Thyroid Cancer Recurrence.Semantic proximity Read ↗

BRAF V600E status adds incremental value to current risk classification systems in predicting papillary thyroid carcinoma recurrence.Semantic proximity Read ↗

BRAF mutation in papillary thyroid carcinoma: predictive value for long-term prognosis and radioiodine sensitivity.Semantic proximity Read ↗

Association Between <i>BRAF</i> V600E Mutation and Recurrence of Papillary Thyroid CancerSemantic proximity Read ↗

BRAF V600E Mutation Lacks Association with Poorer Clinical Prognosis in Papillary Thyroid Carcinoma.Semantic proximity Read ↗

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Clinical significance of BRAF (V600E) mutation and Ki-67 labeling index in papillary thyroid carcinomas.Semantic proximity Read ↗

BRAF mutation testing of thyroid fine-needle aspiration biopsy specimens for preoperative risk stratification in papillary thyroid cancer.Semantic proximity Read ↗

BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer.Semantic proximity Read ↗

Response to therapy of papillary thyroid cancer of known BRAF status.Semantic proximity Read ↗

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