Article

Conserved copper(I)-binding auxiliary domains link virulence-associated LPMOs to copper homeostasis in the intestinal environment

2026-08-06

Abstract excerpt

Multidomain lytic polysaccharide monooxygenases (LPMOs) are widely distributed in human pathogenic bacteria and increasingly recognized for promoting host interactions and virulence. Recent work has shown that immunizing mice with CbpD, a trimodular LPMO from Pseudomonas aeruginosa , provides protection against lethal P. aeruginosa infection. In several human intestinal pathogenic bacteria, LPMOs occur as tetra-...

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Literature Corpus work: 98ee907d-faef-5ce5-9d96-c4f7ee7668f4
DOI: 10.64898/2026.08.05.742968

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