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Article

Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma

28 Apr 2016

Abstract excerpt

To interrogate signaling pathways activated in mantle cell lymphoma (MCL) in vivo, we contrasted gene expression profiles of 55 tumor samples isolated from blood and lymph nodes from 43 previously untreated patients with active disease. In addition to lymph nodes, MCL often involves blood, bone marrow, and spleen and is incurable for most patients. Recently, the Bruton tyrosine kinase (BTK) inhibitor ibrutinib...

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PMID: 27127301
DOI: 10.1182/blood-2015-11-681460

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