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Article

Targeting B-cell receptor and PI3K signaling in diffuse large B-cell lymphoma

28 Jul 2021

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous diagnostic category comprising distinct molecular subtypes characterized by diverse genetic aberrations that dictate patient outcome. As roughly one-third of patients with DLBCL are not cured by current standard chemoimmunotherapy, a better understanding of the molecular pathogenesis is warranted to improve outcome. B-cell receptor (BCR) signaling is...

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PMID: 34320160
DOI: 10.1182/blood.2020006784

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