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Article

Mutation of rnf213a by TALEN causes abnormal angiogenesis and circulation defects in zebrafish.

Brain research - 1 Aug 2016

Wen Jun, Sun Xunsha, Chen Huimin, Liu Huijiao, Lai Rong, Li Jiaoxing, Wang Yufang, Zhang Jingjing, Sheng Wenli

Abstract excerpt

Moyamoya disease (MMD) is characterized by a stenosis at the terminal of the internal carotid artery and an abnormal vascular network at the base of the brain. RNF213 is a susceptibility gene for MMD in East Asians. The role of RNF213 in the etiology of MMD remains unknown. Here we generated rnf213a mutant zebrafish using transcription activator-like effector nuclease (TALEN) technique and described the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27125596
DOI: 10.1016/j.brainres.2016.04.051

Genes

MMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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