Article
Furin Cleavage of L2 during Papillomavirus Infection: Minimal Dependence on Cyclophilins.
Journal of virology - 15 Jul 2016
Bronnimann Matthew P, Calton Christine M, Chiquette Samantha F, Li Shuaizhi, Lu Mingfeng, Chapman Janice A, Bratton Kristin N, Schlegel Angela M, Campos Samuel K
Abstract excerpt
UNLABELLED: Despite an abundance of evidence supporting an important role for the cleavage of minor capsid protein L2 by cellular furin, direct cleavage of capsid-associated L2 during human papillomavirus 16 (HPV16) infection remains poorly characterized. The conserved cleavage site, close to the L2 N terminus, confounds observation and quantification of the small cleavage product by SDS-PAGE. To overcome this...
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