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A Major Role for the Minor Capsid Protein of Human Papillomavirus Type 16 in Immune Escape

29 Oct 2009

Abstract excerpt

High-risk human papillomavirus (HPV) infection of the cervical epithelium is causally linked with the generation of cervical cancer. HPV does not activate Langerhans cells (LC), the APC at the site of infection, leading to immune evasion. The HPV protein responsible for inducing this immune escape has not been determined. We demonstrate that LC exposed to the minor capsid protein L2 in HPV16L1L2 virus-like...

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PMID: 19864613
DOI: 10.4049/jimmunol.0902145

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