Article
A membrane-destabilizing peptide in capsid protein L2 is required for egress of papillomavirus genomes from endosomes.
Journal of virology - 1 Jan 2006
Kämper Nadine, Day Patricia M, Nowak Thorsten, Selinka Hans-Christoph, Florin Luise, Bolscher Jan, Hilbig Lydia, Schiller John T, Sapp Martin
Abstract excerpt
Papillomaviruses are internalized via clathrin-dependent endocytosis. However, the mechanism by which viral genomes pass endosomal membranes has not been elucidated. In this report we show that the minor capsid protein L2 is required for egress of viral genomes from endosomes but not for initial uptake and uncoating and that a 23-amino-acid peptide at the C terminus of L2 is necessary for this function....
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